Professor of Molecular & Cellular Immunology
University of Amsterdam, the Netherlands
Prof. Teunis Geijtenbeek is head of the department of Experimental Immunology at the Academic Medical Center in Amsterdam. His group studies the function of pattern recognition receptor on human dendritic cells in viral infections and adaptive immunity to pathogens. Over the past years, his group has identified novel signaling pathways in dendritic cells that shape adaptive immunity to HIV-1 and M. tuberculosis. He has shown that DC-SIGN on dendritic cells induces carbohydrate-specific signaling that leads to Th1, Th2 or follicular Th cell responses. Furthermore, he has shown that viruses target C-type lectins to suppress antiviral immune responses.
Currently he is investigating methods to reprogram DC function and overcome tolerance observed in cancer as well as during viral infections.